Partners

1a. Karolinska institutet, Stockholm, Sweden

Professor Bengt Fadeel is the NANOMMUNE Project Coordinator. Together with assistance from the Management Office, he is responsible for continuous coordination and monitoring of the project, including scientific, administrative and financial aspects. Bengt Fadeel is also a scientific advisor to the Swedish Research Council on a project focused on dissemination of nanotechnologies to the general public. The focus of his research has been on programmed cell death (apoptosis) and in particular on cell death in the immune system. 

Within the NANOMMUNE project his lab will study the role of specific receptors involved in EN particle uptake in vitro. Moreover, it will be investigated whether EN particle uptake interferes with subsequent clearance of apoptotic cells in vitro, which could influence tissue homeostasis and inflammation. Most of these activities are conducted within NANOMMUNE Work Package 3 (WP3).

 

Group members:

  • Bengt Fadeel, M.D., Ph.D. (Professor, Project Coordinator)
  • Erika Witasp, PhD. (Project Manager)
  • Andreas Ek, Msc. (Project Administrator)
  • Andrea Kunzmann, Ph.D. (postdoctoral fellow)
  • Jingwen Shi, Msc. (PhD student)

 

Read more » (opens in new window)

 

Selected publications:

  1. Witasp E, Kupferschmidt N, Bengtsson L, Hultenby K, Smedman C, Paulie S, Garcia-Bennett AE, Fadeel B.

    Efficient internalization of mesoporous silica particles of different sizes by primary human macrophages without impairment of macrophage clearance of apoptotic or antibody-opsonized target cells

    Toxicol Appl Pharmacol. 2009 Sep 15;239(3):306-19. Read » (opens in new window) 

  2. Witasp E, Shvedova AA, Kagan VE, Fadeel B.

    Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses.

    Inhal Toxicol. 2009 Jul;21(S1):131-136. Read » (opens in new window) 

  3. Shvedova AA, Kisin ER, Murray AR, Kommineni C, Castranova V, Fadeel B, Kagan VE. 
    Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes
    Toxicol Appl Pharmacol. 2008 Sep 1;231(2):235-40. Read » (opens in new window)

   

1b. Karolinska institutet, Stockholm, Sweden

The lab of Professor Annika Scheynius at the Clinical Allergy Research Unit has a solid expertise in dendritic cell biology and how to modify immune responses.

Within NANOMMUNE the lab will conduct in vitro experiments (WP3) on effects of EN on primary human dendritic cells and the subsequent cellular interactions with lymphocytes and will also participate in the in vivo assessments of ENs (WP4).  The lab will also perform studies on endogenous biological nano-sized particles (exosomes).

 

Group members:

  • Annika Scheynius, M.D., Ph.D. (Professor)
  • Susanne Gabrielsson, Ph.D. (Associate Professor)
  • Britta Andersson, Ph.D. (postdoctoral fellow)
  • Khaleda Qhazi, Ph. D. (postdoctoral fellow)
  • Helen Vallhov (PhD student)
  • Mikael Karlsson, Ph.D. (Associate Professor)
  • Emilie Domange Jordö (PhD student)

 

Read more » (opens in new window)

 

Selected publications

  1. Admyre C,Telemo E, Almqvist N, Lötvall J, Lahesmaa R, Scheynius A, Gabrielsson S.Exosomes - nanovesicles with possible roles in allergic inflammation.Allergy. 2008 Apr;63(4):404-8. Read » (opens in new window) 
  2.  Admyre C, Johansson SM, Qazi KR, Filén JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S.  Exosomes with immune modulatory features are present in human breast milk.J Immunol. 2007 Aug 1;179(3):1969-78. Read » (opens in new window) 
  3.  Admyre C, Bohle B, Johansson SM, Focke-Tejkl M, Valenta R, Scheynius A, Gabrielsson S. B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce Th2-like cytokines. J Allergy Clin Immunol. 2007 Dec;120(6):1418-24. Read » (opens in new window)