Partners

9. National Institute for Occupational Safety and Health, NIOSH,
Morgantown WV, USA

Professor of Physiology and Pharmacology Anna Shvedova will act as the coordinator for Work Package 4 which is responsible for in vivo assessment of nanomaterials. The focus of her research has been mainly on in vivo assessment of toxic effects of nanomaterials after pulmonary and dermal exposures affecting the respiratory immune system.

In the NANOMMUNE project Shvedova’s lab will evaluate mechanisms of pulmonary toxicity in response to in vitro or in vivo exposure to carbon nanotubes. The major aims are to develop inhalation exposure systems and to study mechanisms of cytotoxicity of carbon nanotubes in culture systems of cells in the respiratory tract. The in vivo samples obtained by these studies will also be analyzed by in silico assessment in WP5.

Group members:

  • Anna Shvedova, PhD. (Professor)
  • Ashley Murray, PhD. (postdoctoral fellow)
  • Elena Kisin (Research scientist)

Read more » (opens in new window)

Selected publications:

  1. Shvedova AA, Kisin E, Murray AR, Johnson VJ, Gorelik O, Arepalli S, Hubbs AF, Mercer RR, Keohavong P, Sussman N, Jin J, Yin J, Stone S, Chen BT, Deye G, Maynard A, Castranova V, Baron PA, Kagan VE.
    Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis.
    Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):552-65. Read » (opens in new window)
  2. Shvedova AA, Kisin ER, Murray AR, Kommineni C, Castranova V, Fadeel B, Kagan VE.
    Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes.
    Toxicol Appl Pharmacol. 2008 Sep 1;231(2):235-40. Read » (opens in new window)
  3. Shvedova AA, Kisin ER, Murray AR, Gorelik O, Arepalli S, Castranova V, Young SH, Gao F, Tyurina YY, Oury TD, Kagan VE.
    Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice.
    Toxicol Appl Pharmacol 2007;221:339-348. Read » (opens in new window)