Partners

10a. North Carolina State University, Center for Chemical Toxicology Research and Pharmacokinetics, NC, USA

 

Professor  NancyMonteiro-Riviere  is a Toxicologist with extensive experience incomparative dermatotoxicology, in vitro skin absorption and penetrationmodels. Her laboratory researchstudies the dermal effects of toxicity and inflammation with several types of manufactured nanomaterials. The focus of  her researchinvolves nanomaterial toxicity, inflammation localization, skinpenetration and absorption, biodistribution in cells, tissues,pharmacokinetics.  Recently, her lab has published the mechanisms of quantum dot cellular uptake and localization within the cellular compartment in cells. http://cctrp.ncsu.edu/ 

In the NANOMMUNE project these topics will be further evaluated by participation in WP 4.

 

Group members:

  • Nancy Monteiro-Riviere, Ph.D. (Professor)
  • Jim Riviere, DVM, Ph.D, Dsc (hon) (Distinguished Professor of Pharmacology)
  • Xin Xia, Ph.D. (Research Assistant Professor)
  • Alfred Inman, MS (Lab manager and research associate)
  • Jim Brooks, MS (Lab manager and research associate)
  • James Yeatts, MS (Analytical Chemist)
  • Elisha Koivisto, BS (Surgical Technician)
  • L. Zhang (PhD student)
  • M. Samberg (PhD student)
  • H. Lee (PhD student)

 

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Selected publications:

  1. Monteiro-Riviere NA, Inman AO, Zhang LW.Limitations and relative utility of screening assays to assesengineered nanoparticle toxicity in a human cellline. Toxicology and Applied Pharmacology 234: 222-235, 2009. Read » (opens in new window)
  2. Zhang LW, Monteiro-Riviere NA.  Mechanisms of quantum dotnanoparticle cellular uptake. Toxicological Sciences 110:138-155, 2009 Read » (opens in new window)
  3. Lee HA, Leavens T, Mason SE, Monteiro-Riviere NA, Riviere JE. Comparison of quantum dot distribution with a bloodflow-limited physiologically based pharmacokinetic model. Nano Letters 9: 794-799, 2009. Read » (opens in new window)
  4. Zhang LW, Yu WW, Colvin VL, Monteiro-Riviere NA. Biological interactions of quantum dot nanoparticles in skin an in human epidermal keratinocytes. Toxicol Appl Pharmacol. 2008 Apr 15;228(2):200-11. Read » (opens in new window)

 

10b. North Carolina State University, Center for Chemical Toxicology Research and Pharmacokinetics, NC, USA

Jim Riviere is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology and Toxicology and isinvolved with the vivo assessment (WP4) and the mathematical modelingaspects of this project that will allow integration of the results into a risk assessment framework (WP6). His current research interests involve applying biomathematics to problems in toxicology, including the risk assessment of chemical mixtures, pharmacokinetics, nanomaterials, absorption of drugs and chemicals across skin. Jim Riviere has had extensive experience in integrating data from experimental systems using in silico models that are useful for in vivo predictions.

 

Group members:

  • Jim Riviere, PhD. (Distinguished Professor of Pharmacology)
  • Jim Brooks, MS (Lab manager and research associate) 
  • T. Leavens, PhD. (Research Assistant Professor)
  • Xin Xia, Ph.D. (Research Assistant Professor)
  • Beth Barlow, BS (Research technician)
  • Hyun Lee (PhD student)
  • Jason Chittenden ( PhD student)
  • Lindsey Waltman ( PhD student)

Read more » (opens in new window)

 

Selected publications:

  1. Lee HA, Leavens TL, Mason SE, Monteiro-Riviere NA, Riviere JE. Comparison of quantum dot biodistribution with a blood-flow-limitedphysiologically based pharmacokinetic model. Nano Letters 794-799, 2009. Read » (opens in new window)
  2. Monteiro-Riviere NA and Riviere JE. Interaction of nanomaterials with skin: Aspects of absorption and biodistribution. Nanotoxicology 3(3): 188-193, 2009. Read » (opens in new window)
  3. Xia XR, Monteiro-Riviere NA, Riviere JE. Skin penetration andkinetics of pristine fullerenes (C60) topically exposed in industrialorganic solvents. Toxicology Applied Pharmacology. In press  Read » (opens in new window)
  4. Lee HA, Imran M, Monteiro-Riviere NA, Colvin VL, Yu WW, Riviere JE. Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating dependency and periodicity in arterial extraction. Nano Lett. 2007 Sep;7(9):2865-70- Read » (opens in new window)