Workplan   Several classes of well selected nanomaterials are studied from the synthesis of the nanomaterials, immunotoxicity testing to the overall risk assessment. The specific expertise of our partners contributes to a unique multidisciplinary project, which is essential when studying toxicity of nanomaterials. The NANOMMUNE project is divided in 7 work packages:     WP1 - Project Management Management and administration of all activities in the other work packages. WP2 - Synthesis and Physico-chemical characterization   Generation, modification and characterization of various classes of custom designed nanomaterials and benchmarking of commercial nanomaterials.   WP3 - In vitro assessment and mechanistic studies Investigates the mechanisms and signaling pathways of particle-cell and cell-cell interactions after exposure of primary cells and cell lines to nanomaterials in vitro. WP4 - In vivo assessment and confirmation Studies the immunotoxic effects of in vivo exposure to nanomaterials focusing on tissue damage, pharmacokinetic dynamics and distribution.  WP5 - High throughput in silico assessment Establishes nanotoxic signatures by performing lipidomics and transcriptomics analyses of samples derived in after in vitro (WP3) and in vivo (WP4) exposure with nanoparticles. WP6 - Modeling and risk assessment Aims to develop a structure based paradigm for assessing the toxicological hazard of nanomaterials by using the data obtained in the other work packages. These results will be published on the risk assessment database. WP7 - EU-US coordination and dissemination Coordinates the implementation and distribution of the results obtained in the project.   Abbreviations KI; Karolinska Institutet, KTH; Royal Academy of Sciences, UU; Uppsala University, UCO; University of Cologne, UT; University of Turku, EMPA; Swiss Federal Laboratories for Materials Testing and Research, IOM; Institute of Occupational Medicine, UP; University of Pittsburgh, NIOSH; National Institute for Occupational Safety and Health, NCSU; North Carolina State University.